This part of the E4 European trail starts from Anogia, arrives at ancient Zominthos and finishes at Nida Plateau. Due to being quite long, it is used to split the trail into two parts (Anogia - Zominthos and Zominthos - Nida). The route offers a very good experience of the typical rocky terrain of the Range Psiloritis. During winter, it is very possible to meet snow.
From Ziros, the E4 European trail heads northeastwards and soon enters a dirt road that leads to ruined historic settlement Skalia. From Skalia we walk north and east, we pass a small plateau and then descend to Ano Zakros springs.
This E4 part starts from the village Thrypti and heads southeastwards and through dirt roads finishes at Dafni village. The route is very easy, thus being ideal for cycling. The trail comes through the lush green village Orino, the starting point of Orino Gorge. The route continues to the east and crosses the village Hrissopigi, before ending at Dafni.
From the gorgeous pine wood of Selakano, the E4 European trail follows the stream to the south of peak Koreli. Through this, we reach the settlement Rousoxyla and then Prina.
From Profitis Elias, the E4 European Trail runs along a dirt road that passes north of the fortress Roka (Temenos) and via a network of dirt roads, through vineyards and oliveyards, reaches the western slope of Mount Youchtas, near the village Karnari. Then, through asphalt road, we bypass Youchtas from the south side and follow the dirt road that climbs to the Youchtas and soon we enter the trail to Archanes.
The area of Moundros hosts two different trails which are parts of the E4 European trail. The one heads to the east and after crossing the position Nifis Potamia heads to the village Agouseliana. The entire trail is via paved and dirt track, being an ideal cycling route.
This route offers some nice views of the fertile hinterland of Rethymnon, mainly using dirt and paved roads. The route starts from Agios Konstantinos, crosses Kalonihtis and Ano Valsamonero, before reaching Monopari, then Kastelos, and finishes at Armeni Minoan necropolis.